Ibuprofen and Acetaminophen Combo As Effective as Opioid Analgesia for Acute Pain

By Martina McGrath, MD
November 9, 2017

The opioid epidemic is the preeminent public health crisis facing the US today. In recent days, the CDC has reported that opioid overdose deaths rose by 17% in 2016, and the annual rate of fatal overdose deaths now stands at 20 per 100,000 people.1

While multiple factors have been implicated in driving the epidemic, Continue reading “Ibuprofen and Acetaminophen Combo As Effective as Opioid Analgesia for Acute Pain”

Oxygen in Acute MI: Lack of Benefit and Possible Risk?

By Martina McGrath, MD
November 3, 2017

Acute myocardial infarction occurs where there is insufficient supply of oxygenated blood to an area of the heart, leading to myocardial injury and cell death. For decades, clinical guidelines have recommended the administration of supplemental oxygen as a first-line therapy for all patients experiencing myocardial ischemia, regardless of oxygen saturation.1 Continue reading “Oxygen in Acute MI: Lack of Benefit and Possible Risk?”

Sodium Restriction in Patients with Reduced GFR: Blood Pressure Benefits

By Martina McGrath, MD
October 18, 2017

The typical US diet is comprised of 3.4g of sodium per day on average, whereas current recommendations suggest that sodium intake should be limited to <2g/day for the general population1 and possibly lower for those with hypertension or cardiovascular disease.2 Continue reading “Sodium Restriction in Patients with Reduced GFR: Blood Pressure Benefits”

Increased Risk of Adverse Pregnancy Outcomes after Recovery from Acute Kidney Injury

By Martina McGrath, MD
September 26, 2017

Women with advanced chronic kidney disease (CKD) have long been known to be at increased risk of complications in pregnancy including preeclampsia, pre-term birth, small-for-dates offspring, and progression of underlying CKD following pregnancy.1 However, several recent studies have highlighted a less obvious connection between earlier stages of renal disease and adverse pregnancy outcomes.2,3 Continue reading “Increased Risk of Adverse Pregnancy Outcomes after Recovery from Acute Kidney Injury”

Palliative Care in Advanced Heart Failure

By Connor Emdin
September 20, 2017

Heart failure (HF) is the leading cause of hospitalization for adults over the age of 65 in the United States and is associated with poor short-term survival, with an estimated median survival of 1.5-3 years after diagnosis.1,2 In addition to causing significant morbidity and mortality, HF is associated with reduced quality of life, spiritual distress, depression, and anxiety.3
Continue reading “Palliative Care in Advanced Heart Failure”

Taking Personalized Medicine to a New Level: CAR-T Cell Therapy

By Martina McGrath, MD
September 13, 2017

Each individual is estimated to have around 4 x 1011 T cells, comprising many millions of T cell clones,1 each randomly produced in the thymus with a unique T cell receptor (TCR) specific for a given antigen. This massive diversity in T cell repertoire gives our immune systems the capacity to protect against the incredible array of bacteria, viruses and fungi that assail us on a constant basis. Continue reading “Taking Personalized Medicine to a New Level: CAR-T Cell Therapy”

Quality of Life & Cost-Effectiveness of Intensive Blood Pressure Lowering

By Connor Emdin
September 6, 2017

In recent years, there has been considerable shift in treatment targets for blood pressure management. In 2014, the Eighth Joint National Commission (JNC 8) guidelines controversially up-revised blood pressure targets and recommended a target blood pressure of less than 140/80mm Hg in adults less than 60 years of age, increasing to less than 150/90mm Hg in those aged over 60 years. They argued that at the time, no randomized trial had demonstrated that lower blood pressure targets were associated with reduced risk of cardiovascular disease or death.1 These recommendations were a cause of heated debate and were inconsistent with recommendations from several other expert bodies, including American Heart Association and American College of Cardiology. Continue reading “Quality of Life & Cost-Effectiveness of Intensive Blood Pressure Lowering”