Severe C. Difficile Infection: Vancomycin or Metronidazole as First-Line Therapy?

By Martina M. McGrath, MD
February 16, 2017

In 2011, there were almost half a million cases of Clostridium difficile (C. diff) infection in the US and 29,000 patients died from this disease.1 Initially recognized in the 1970s, a more virulent strain appeared in the early 2000s with increased associated mortality. Now one of the commonest health care-associated infections, C. diff has a disproportionate impact on patients who are frail, immunosuppressed, and malnourished. Between 15 and 50% of patients can suffer from recurrent C. diff infection, leading to increased health care costs and further risk of complications. Continue reading “Severe C. Difficile Infection: Vancomycin or Metronidazole as First-Line Therapy?”

Candida Auris—A New Deadly Fungus

By Ajay Singh, MBBS, FRCP
November 10, 2016

There are few things that wake federal health officials up at night. One is the possibility of a deadly infection that might spread throughout the United States.

In an article in the MMWR, Snigdha Vallabhaneni from the Center for Disease Control (CDC) and colleagues report seven cases in the United States of a potentially deadly drug-resistant fungal infection—Candida auris. Continue reading “Candida Auris—A New Deadly Fungus”