Procalcitonin-Guided Antibiotic Therapy in Lower Respiratory Tract Infection: Is It Safe?

By Martina McGrath, MD
June 5, 2018

Pulmonary infection is one of the most common reasons for hospitalization in the US. Overprescription of antibiotics, due either to inappropriate initiation or excessive treatment duration, is an important contributor to antibiotic resistance and complications of therapy.1.2 Continue reading “Procalcitonin-Guided Antibiotic Therapy in Lower Respiratory Tract Infection: Is It Safe?”

Nitrofurantoin versus Fosfomycin for Acute Uncomplicated Cystitis

By Martina McGrath, MD
May 9, 2018

Acute uncomplicated cystitis is defined as infection localized to the bladder without signs of further extension such as fever, flank pain/tenderness, or systemic symptoms. It is a highly prevalent problem and over half of all women experience at least one urinary tract infection (UTI) in their lifetime.1 In otherwise healthy women, with normal urinary tract anatomy, treatment can commonly be instituted without the need for urine culture. Both nitrofurantoin and fosfomycin are currently recommended as first-line agents for treatment of uncomplicated cystitis. However, some older studies have suggested that fosfomycin may have inferior efficacy.2 Continue reading “Nitrofurantoin versus Fosfomycin for Acute Uncomplicated Cystitis”