The Emergence of NK Cell-Based Treatment in Cancer Immunotherapy

By Olivier Lucar
August 20, 2019

The 2018 Nobel Prize in Physiology or Medicine was awarded to James Alison and Tasuku Honjo for their groundbreaking work on cancer therapy targeting the inhibition of immune checkpoints (IC), proteins that negatively regulate the immune response. Their work was groundbreaking because it opened a new powerful tool for the cure of cancer—immunotherapy (Fritz J. et Lenardo M., 2019).

The Cancer Revolution

At the beginning of cancer research, the immune system was not considered an important actor in cancer pathogenesis. But, in fact, the tumor microenvironment is Continue reading “The Emergence of NK Cell-Based Treatment in Cancer Immunotherapy”

Worldwide Trends in HIV Vaccine: Are We There Yet?

By Olivier Lucar
October 16, 2018

Chronic HIV infection remains a major public health issue. According to 2017 data from UNAIDS, there are still 36.9 million HIV-positive individuals worldwide, including 1.1 million in the USA, of whom 1 in 7 are unaware of their status. HIV infection usually has a slow and paucisymptomatic infectious development, which makes recognition of infection difficult and leads to its persistence. HIV disproportionately affects individuals in less developed countries and can only be treated with multiple expensive drugs, the availability of which depends on the country. Furthermore, despite the phenomenal progress in anti-HIV drug efficacy (leading to sustained undetectable levels of viral load), long-term infection and treatment are associated with other comorbidities from cardiovascular diseases to certain cancers (Taiwo et al., 2013). The search for therapeutic or prophylactic vaccines remains the best option to fight HIV and prevent its permanent development. Continue reading “Worldwide Trends in HIV Vaccine: Are We There Yet?”