Treatment Choice Influences Malignancy Risk in Patients with ANCA Vasculitis

By Martina M. McGrath, MD
March 2, 2017

Publication of the RAVE and Rituxivas trials ushered in a new era of treatment of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Previously, cyclophosphamide was first-line therapy, but treatment was commonly complicated by infection and malignancy, leading to the search for less toxic alternative regimens. RAVE and Rituxivas demonstrated equivalent efficacy in treatment of AAV with either cyclophosphamide or rituximab, with similar numbers of adverse events.1,2 Unexpectedly, more malignancies were observed in rituximab-treated patients in both studies. However, absolute numbers were small, and the significance of this finding was unclear. Follow-up data and clinical experience would suggest that rituximab is well tolerated for treatment of AAV, including when used as maintenance therapy.3,4 Continue reading “Treatment Choice Influences Malignancy Risk in Patients with ANCA Vasculitis”